BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab01489(CD59 antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab01489(CD59 antibody) at dilution of 1:100
Background
Potent inhibitor of the complement membrane attack complex(MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.